ABSTRACT
No abstract available.
Subject(s)
Eosinophilia , Eosinophils , Folliculitis , Mucous Membrane , Naproxen , Skin Diseases, VesiculobullousABSTRACT
No abstract available.
Subject(s)
Eosinophilia , Eosinophils , Folliculitis , Mucous Membrane , Naproxen , Skin Diseases, VesiculobullousABSTRACT
A synthetic analogue of calcitriol (1,25-dihydroxymitamin D3), has shown immunomodulatory effects as well as induction of cell differentiation and inhibition of cell proliferation. This agent has been widely used for psoriasis. We report a case of seborrheic keratosis of the left areola in a 33-year-old female who was treated with calcipotriol ointment. Because of the lesion's location and shape, it was difficult to try ablative methods. However, complete disappearance of the lesion was observed after 6 weeks of topical calcipotriol application. This case suggests that the calcipotriol ointment is effective in the treatment of seborrheic keratosis.
Subject(s)
Adult , Female , Humans , Calcitriol , Cell Differentiation , Cell Proliferation , Keratosis, Seborrheic , PsoriasisABSTRACT
Febrile ulceronecrotic pityriasis lichenoides et varioliformis acuta (PLEVA), or febrile ulcerative Mucha-Haberman disease (FUMHD) is very rare, but potentially lethal variants of PLEVA. This subtype is characterized by rapidly progressive ulceronecrotic lesions and systemic manifestations, such as high fever, gastrointestinal, neurological, cardiologic and pulmonary involvement, and rheumatologic manifestations. Several treatments with variable response have been challenged, such as systemic steroid, antibiotics, methotrexate, dapsone, cyclosporine and ultraviolet therapy. But there is no standard therapy for FUMHD to date. We report a 59-year-old woman with FUMHD, who recurred after discontinuation of systemic steroid, but successfully treated with oral cyclosporine.
Subject(s)
Female , Humans , Middle Aged , Anti-Bacterial Agents , Cyclosporine , Dapsone , Fever , Methotrexate , Pityriasis , Pityriasis Lichenoides , Ulcer , Ultraviolet TherapyABSTRACT
We report a case of tinea incognito in a 29-year-old man after applying the 0.03% tacrolimus ointment. He was known atopic dermatitis patient and has been treated with intermittent application of tacrolimus. For his facial pruritus 0.03% tacrolimus ointment was prescribed, and after one week he developed annularly grouped erythematous plaques and patches around the ointment-applied area. The KOH smear revealed multiple fungal hyphae. Dermatologists should be aware of the possibility of topical tacrolimus to be the causative agent for tinea incognito.
Subject(s)
Dermatitis, Atopic , Hyphae , Pruritus , Tacrolimus , TineaABSTRACT
Therapeutic options for infantile hemangioma are limited. The nonselective beta-adrenergic receptor antagonist propranolol is an effective therapy for infantile hemangiomas. However, systemic propranolol carries a risk of serious side effects, including bradycardia, hypoglycemia, arrhythmias, hypotension and bronchospasm. Recently, treatment of infantile hemangioma with topical timolol (nonselective beta-blocker similar to propranolol) has been reported. We treated successfully the perineal ulcerative hemangioma with topical timolol. We believe that timolol is a safe and effective topical agent and should be strongly considered as one of good therapeutic options for hemagnioma.
Subject(s)
Arrhythmias, Cardiac , Bradycardia , Bronchial Spasm , Hemangioma , Hypoglycemia , Hypotension , Propranolol , Timolol , UlcerABSTRACT
Therapeutic options for infantile hemangioma are limited. The nonselective beta-adrenergic receptor antagonist propranolol is an effective therapy for infantile hemangiomas. However, systemic propranolol carries a risk of serious side effects, including bradycardia, hypoglycemia, arrhythmias, hypotension and bronchospasm. Recently, treatment of infantile hemangioma with topical timolol (nonselective beta-blocker similar to propranolol) has been reported. We treated successfully the perineal ulcerative hemangioma with topical timolol. We believe that timolol is a safe and effective topical agent and should be strongly considered as one of good therapeutic options for hemagnioma.
Subject(s)
Arrhythmias, Cardiac , Bradycardia , Bronchial Spasm , Hemangioma , Hypoglycemia , Hypotension , Propranolol , Timolol , UlcerABSTRACT
No abstract available.
Subject(s)
Arteriovenous Malformations , Embolization, Therapeutic , Telangiectasia, Hereditary HemorrhagicABSTRACT
Fibroma of the tendon sheath is an uncommon soft tissue tumor presenting as a solitary, slow-growing, firm, painless, small nodule, which shows strong attachment to the tendon or tendon sheath. It is usually localized on fingers and hand tendons in adults between the age of 20 and 40 years old. This case concerns a 61-year-old man presenting with a 5-year history of multiple cutaneous nodules on both palms and soles. Skin biopsy confirmed fibroma of the tendon sheath. Blood tests showed a high titer of rheumatoid factor and positivity to anti-nuclear antibody. No case of fibroma of the tendon sheath occurring multifocally on both palms and soles has been previously reported. Herein, we report on a very rare case of multiple fibromas of the tendon sheath arising from palms and soles, which supports the pathogenetic hypothesis that this tumor may be a reactive process rather than a true neoplasm.
Subject(s)
Adult , Humans , Middle Aged , Biopsy , Fibroma , Fingers , Hand , Hematologic Tests , Rheumatoid Factor , Skin , TendonsABSTRACT
Multiple congenital melanocytic nevi (MCMN), defined as the distribution of more than three small- or medium- sized congenital melanocytic nevi (CMN) on the body without a giant CMN, is a rare disease comprising about 4% of patients with CMN. Because MCMN accompanies neurodevelopmental delay, including seizures in 25% of patients as well as the risk of malignant melanoma, it must be carefully followed-up. We report a case of MCMN with developmental delay in a 19-month-old Korean boy. He had a history of febrile seizure when he was 18 months old. He showed a speech delay after the 1-year-follow up, even though there was no evidence of neurocutaneous melanosis (NCM) on brain magnetic resonance imaging (MRI) at the first visit. As MRI has a low sensitivity for detecting NCM in patients with MCMN older than 4-months, close neurodevelopmental assessments should be considered to provide a chance for early rehabilitation.
Subject(s)
Humans , Infant , Brain , Language Development Disorders , Magnetic Resonance Imaging , Melanoma , Melanosis , Neurocutaneous Syndromes , Nevus, Pigmented , Rare Diseases , Seizures , Seizures, FebrileABSTRACT
Seborrheic keratosis is one of the most common benign epithelial tumors, especially in elderly patients. Squamous cell carcinoma is the second most common malignant tumor of the skin. Despite the fact that both tumors are common, malignant transformation of seborrheic keratosis rarely occurs. Herein we report a case of squamous cell carcinoma arising in a patient with pre-existing seborrheic keratosis.
Subject(s)
Aged , Humans , Carcinoma, Squamous Cell , Keratosis, Seborrheic , SkinABSTRACT
Mycosis fungoides (MF) is the most frequent cutaneous T cell lymphoma (CTCL). Since the major tumor cell of MF is the helper T cell, positive markers are usually CD3, CD4 and CD45RO. Some MFs show CD30 positivity and the major differential diagnosis for MF with CD30 positivity includes transformed MF and MF concurrent with primary cutaneous anaplastic large cell lymphoma and lymphomatoid papulosis. As each disease shows a different prognosis, an exact diagnosis is crucial for proper treatment. We now report a case of 44-year-old male patient with mycosis fungoides which developed several papules on preexisting MF patches. On biopsy of the newly formed papules, CD 30 positive cells were observed and the histologic features were consistent with lymphomatoid papulosis. Both the lesions of lymphomatoid papulosis and MF responded well to narrow band ultraviolet B phototherapy.
Subject(s)
Adult , Humans , Male , Biopsy , Diagnosis, Differential , Lymphoma, Primary Cutaneous Anaplastic Large Cell , Lymphoma, T-Cell, Cutaneous , Lymphomatoid Papulosis , Mycosis Fungoides , Phototherapy , PrognosisABSTRACT
Lupus pernio is the most characteristic cutaneous lesion of sarciodosis and this presents as an indurated red to blue-purple, swollen, shiny lesion that is often localized on the nose, cheeks, lips or ears of middle-aged female adults. It is a chronic malady that rarely shows spontaneous remission, and it sometimes causes deformity. It generally occurs as cutaneous lesions of sarcoidosis patients with a long duration of disease, and not as early cutaneous lesions of sarcoidosis. This case concerns a 43-year-old woman who presented with a 1 year history of firm erythematous and violaceous plaque with multiple erythematous and violaceous papules on the collumella and right nasal cavity. Skin biopsy showed noncaseasting granuloma. Herein, we report on a typical case of lupus pernio as the early cutaneous presentation of sarcoidosis, which has rarely been reported in the Korean literature. We suggest that early diagnosis and treatment is necessary to prevent deformity.
Subject(s)
Adult , Female , Humans , Biopsy , Cheek , Congenital Abnormalities , Ear , Early Diagnosis , Granuloma , Lip , Nasal Cavity , Nose , Remission, Spontaneous , Sarcoidosis , SkinABSTRACT
Chemical leukoderma occurs due to the toxic effect of a specific chemical preceding allergic contact dermatitis. The mechanism is either destruction or inhibition of melanocytes by the offending substance. Clinicohistopathologically, no absolute criteria can differentiate chemical leukoderma from vitiligo. However, chemical leukoderma can be diagnosed clinically by a history of repeated exposure to a known or suspected depigmenting agent at the primary site. There is no agreed treatment guideline for chemical leukoderma. We report a healthy 51-year-old man who had multiple hypopigmented macules and patches on his face, neck, arms and legs after exposure to occupationally related chemicals. The lesions were recalcitrant to topical corticosteroids, but they showed much improvement after 3 cycles of systemic steroid pulse therapy. We suggest this therapy may be a good treatment option for chemical leukoderma.